Antioxidant Evaluations of Novel N-H and N-Substituted Indole Esters
نویسندگان
چکیده
منابع مشابه
N-substituted indole-3-imine derivatives and their amine congeners: antioxidant and Src kinase inhibitory effects.
Current evidences demonstrated that the activity of protein kinases can be controlled through oxidative stress induced by reactive oxygen species (ROS) and normalized by antioxidants. Recent studies with ROS, generated by mitochondria, suggested the potential signalling role of these species, where ROS, especially hydrogen peroxide, were proposed as membrane-related signalling components. The p...
متن کاملSynthesis of N-arylmethyl Substituted Indole Derivatives as New Antiplatelet Aggregation Agents
A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then act...
متن کاملSynthesis of N-arylmethyl Substituted Indole Derivatives as New Antiplatelet Aggregation Agents
A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then act...
متن کاملATTEMPTED PREPARATION OF N-SUBSTITUTED DIPHENYLCYCLOPROPENEIMINE N-OXIDE
The reaction of diphenylcyclopropenone with several N-substituted hydroxylamine and primary amines are investigated. Most of these reactions led to ring opened or ring enlarged products, instead of the desired N-Oxide or imine. The reaction of cyclopropeneimine with peracid-another possible route to N-substituted cyclopropeneimine N-Oxide is studied. Most of the unexpected products are ide...
متن کاملGreen Chemical Synthesis and Biological Evaluation of Novel N-substituted Rhodanine Derivatives as Potential Antifungal Agents
Background and purpose: In medicinal chemistry, molecules containing rhodanine(2-thiazolidine-4-one) ring as a magic multifunctional privileged structural and functional scaffold show a broad range of potent pharmacological properties containing anti-microbial, antiviral, anti-diabetic, and anti-convulsant effects. Evidence suggests that the activity of the rhodanine derivative correlates with ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2003
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.26.736